Elias S J Arnér Selected Research

Thioredoxin-Disulfide Reductase

1/2022	Thioredoxin Reductase Inhibition for Cancer Therapy.
1/2022	Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus.
1/2018	Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.
10/2016	Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
5/2014	Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures.
11/2012	Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury.
1/2011	Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning.
8/2008	Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates.
4/2008	Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells.
3/2006	Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Elias S J Arnér Research Topics

Disease

32	Neoplasms (Cancer) 01/2022 - 03/2006
3	Schistosomiasis (Bilharziasis) 01/2020 - 10/2009
2	Melanoma (Melanoma, Malignant) 01/2022 - 06/2015
2	Rheumatoid Arthritis 01/2020 - 06/2009
2	Ototoxicity 05/2014 - 01/2009
1	Filarial Elephantiasis (Lymphatic Filariasis) 01/2022
1	Autoimmune Diseases (Autoimmune Disease) 01/2022
1	Filariasis 01/2022
1	Onchocerciasis 01/2022
1	Liver Diseases (Liver Disease) 12/2021
1	Chronic Hepatitis B 12/2021
1	Fibrosis (Cirrhosis) 12/2021
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2021
1	Oncogene Addiction 01/2021
1	Multiple Sclerosis 01/2020
1	Infections 01/2020
1	Breast Neoplasms (Breast Cancer) 01/2020
1	Adenocarcinoma 01/2019
1	Lactic Acidosis 01/2019
1	Liver Neoplasms (Liver Cancer) 01/2019
1	Seizures (Absence Seizure) 01/2018
1	Communicable Diseases (Infectious Diseases) 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 05/2017
1	Hypoxia (Hypoxemia) 01/2017
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2016
1	Hepatocellular Carcinoma (Hepatoma) 10/2016
1	Prostatic Neoplasms (Prostate Cancer) 10/2016
1	Chronic Disease (Chronic Diseases) 01/2016
1	Leukemia 06/2015
1	Necrosis 03/2015

Drug/Important Bio-Agent (IBA)

10	Thioredoxin-Disulfide ReductaseIBA 01/2022 - 03/2006
8	ThioredoxinsIBA 01/2022 - 12/2006
8	Selenoproteins (Selenoprotein)IBA 01/2022 - 03/2006
8	AntioxidantsIBA 01/2021 - 02/2008
7	Auranofin (Ridaura)FDA Link 01/2022 - 12/2010
7	EnzymesIBA 01/2022 - 12/2006
6	Pharmaceutical PreparationsIBA 01/2022 - 01/2009
5	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 11/2009
5	Transcription Factors (Transcription Factor)IBA 01/2021 - 02/2008
5	Thioredoxin Reductase 1IBA 01/2020 - 11/2009
4	SelenocysteineIBA 01/2022 - 01/2013
4	Glutathione (Reduced Glutathione)IBA 01/2018 - 11/2012
4	Cisplatin (Platino)FDA LinkGeneric 10/2016 - 01/2009
3	Biomarkers (Surrogate Marker)IBA 12/2021 - 01/2012
2	thioredoxin glutathione reductaseIBA 01/2020 - 01/2018
2	Methionine (L-Methionine)FDA Link 01/2019 - 03/2015
2	PeroxiredoxinsIBA 01/2019 - 08/2008
2	NADP (NADPH)IBA 01/2019 - 03/2015
2	Glutathione Reductase (Glutathione-Disulfide Reductase)IBA 01/2019 - 08/2008
2	Oxidoreductases (Dehydrogenase)IBA 01/2018 - 06/2009
2	NF-E2-Related Factor 2IBA 01/2017 - 11/2012
2	protoporphyrin IXIBA 10/2016 - 05/2011
2	PhytochemicalsIBA 01/2016 - 08/2008
2	Cysteine (L-Cysteine)FDA Link 03/2015 - 08/2008
2	Oxidants (Oxidizing Agents)IBA 05/2014 - 11/2012
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 05/2014 - 01/2009
2	PlatinumIBA 05/2014 - 01/2009
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2013 - 10/2009
2	LigandsIBA 09/2012 - 12/2010
2	Selenious Acid (Selenite)IBA 01/2011 - 12/2006
1	Therapeutic UsesIBA 01/2022
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2022
1	clonidine-displacing substance (ClDS)IBA 12/2021
1	Alanine Transaminase (SGPT)IBA 12/2021
1	Dithiothreitol (Cleland's Reagent)IBA 12/2021
1	aminoflavoneIBA 01/2020
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2020
1	Tamoxifen FDA LinkGeneric 01/2020
1	oncrasin-1IBA 01/2020
1	Hormones (Hormone)IBA 01/2020
1	Dimethyl FumarateIBA 01/2020
1	Estrogens (Estrogen)FDA Link 01/2020
1	Estrogen ReceptorsIBA 01/2020
1	Praziquantel (Biltricide)FDA Link 01/2020
1	Small Interfering RNA (siRNA)IBA 01/2020
1	Bicarbonates (Hydrogen Carbonate)IBA 01/2019
1	Pyruvic Acid (Pyruvate)IBA 01/2019
1	Phenobarbital (Luminal)FDA Link 01/2019
1	peroxycarbonic acidIBA 01/2019
1	Recombinant ProteinsIBA 01/2019
1	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 01/2019
1	Insulin (Novolin)FDA Link 01/2018
1	GlycogenIBA 01/2018
1	NAD (NADH)IBA 01/2018
1	Flavin-Adenine Dinucleotide (FAD)IBA 01/2018
1	Rutin (Rutoside)IBA 05/2017
1	sulforaphaneIBA 01/2017
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 01/2017
1	DeoxyribonucleotidesIBA 01/2017
1	ErbB Receptors (EGF Receptor)IBA 12/2016
1	Proteins (Proteins, Gene)FDA Link 12/2016
1	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 10/2016
1	Glutathione Transferase (Glutathione S-Transferase)IBA 01/2016
1	O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfateIBA 01/2016
1	ProdrugsIBA 01/2016

Therapy/Procedure

11	Therapeutics 01/2022 - 01/2012
4	Drug Therapy (Chemotherapy) 01/2020 - 12/2006
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2022
1	Immunotherapy 01/2022